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Effects of sidechain isomerism on polymer-based non-covalent protein delivery

https://doi.org/10.1039/D2CC02343A

Barrios, Alfonso; Milan, Mario; Perozo, Elianny; Hossen, Md Lokman; Chapagain, Prem; Moon, Joong Ho (July 2022, Chemical Communications)

We present the importance of functional group isomerism on intracellular protein delivery using polymers containing different isomeric side chains. While the physical properties of polymer/protein complexes are relatively similar, different planarity of the isomers greatly influences the cellular entry efficiency.
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Significance of the RBD mutations in the SARS-CoV-2 omicron: from spike opening to antibody escape and cell attachment

https://doi.org/10.1039/D2CP00169A

Hossen, Md Lokman; Baral, Prabin; Sharma, Tej; Gerstman, Bernard; Chapagain, Prem (April 2022, Physical Chemistry Chemical Physics)

We computationally investigated the role of the omicron RBD mutations on its structure and interactions with the surrounding domains in the spike trimer as well as with ACE2. Our results suggest that, compared to WT and delta, the mutations in the omicron RBD facilitate a more efficient RBD “down” to “up” conformation as well as ACE2 attachment. These effects, combined with antibody evasion, may have contributed to its dominance over delta.
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Exploring the Conformational and Binding Dynamics of HMGA2·DNA Complexes Using Trapped Ion Mobility Spectrometry–Mass Spectrometry

https://doi.org/10.1021/jasms.2c00101

Jeanne Dit Fouque, Kevin; Sipe, Sarah N.; Garabedian, Alyssa; Mejia, German; Su, Linjia; Hossen, Md Lokman; Chapagain, Prem P.; Leng, Fenfei; Brodbelt, Jennifer S.; Fernandez-Lima, Francisco (July 2022, Journal of the American Society for Mass Spectrometry)

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Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B.1.617.2 and implications for immune evasion

https://doi.org/10.1016/j.bbrc.2021.08.036

Baral, Prabin; Bhattarai, Nisha; Hossen, Md Lokman; Stebliankin, Vitalii; Gerstman, Bernard S.; Narasimhan, Giri; Chapagain, Prem P. (October 2021, Biochemical and Biophysical Research Communications)

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